Wigginton Group Publications


Qiao, Z., Ye, Y., Szczuka, A., Harrison, K. R., Dodd, M. C., & Wigginton, K. R. (2022). Reactivity of Viral Nucleic Acids with Chlorine and the Impact of Virus Encapsidation. Environmental Science & Technology, 56 (1), 218–227. DOI: 10.1021/acs.est.1c04239

Hughes, B., Duong, D., White, B. J., Wigginton, K. R., Chan, E. M. G., Wolfe, M. K., & Boehm, A. B. (2022). Respiratory Syncytial Virus (RSV) RNA in Wastewater Settled Solids Reflects RSV Clinical Positivity Rates. Environmental Science & Technology Letters, 9 (2), 173–178. DOI: 10.1021/acs.estlett.1c00963

Wolfe, M. K., Topol, A., Knudson, A., Simpson, A., White, B., Vugia, D. J., Yu, A. T., Li, L., Balliet, M., Stoddard, P., Han, G. S., Wigginton, K. R., & Boehm, A. B. (2021). High-Frequency, High-Throughput Quantification of SARS-CoV-2 RNA in Wastewater Settled Solids at Eight Publicly Owned Treatment Works in Northern California Shows Strong Association with COVID-19 Incidence. mSystems6 (5), e0082921. DOI: 10.1128/mSystems.00829-21

Simpson, A., Topol, A., White, B. J., Wolfe, M. K., Wigginton, K. R., Boehm, A. B. (2021). Effect of storage conditions on SARS-CoV-2 RNA quantification in wastewater solids. PeerJ, 9, e11933. DOI: 10.7717/peerj.11933

Borchardt, M. A., Boehm, A. B., Salit, M., Spencer, S. K., Wigginton, K. R., & Noble, R. T. (2021). The Environmental Microbiology Minimum Information (EMMI) Guidelines: QPCR and dPCR Quality and Reporting for Environmental Microbiology. Environmental Science & Technology, 55 (15), 10210–10223. DOI: 10.1021/acs.est.1c01767

Loeb, S. K., Jennings, W. C., Wigginton, K. R., & Boehm, A. B. (2021). Sunlight Inactivation of Human Norovirus and Bacteriophage MS2 Using a Genome-Wide PCR-Based Approach and Enzyme Pretreatment. Environmental Science & Technology, 55 (13), 8783–8792. DOI: 10.1021/acs.est.1c01575

Wolfe, M. K., Archana, A., Catoe, D., Coffman, M. M., Dorevich, S., Graham, K. E., Kim, S., Grijalva, L. M., Roldan-Hernandez, L., Silverman, A. I., Sinnott-Armstrong, N., Vugia, D. J., Yu, A. T., Zambrana, W., Wigginton, K. R., & Boehm, A. B. (2021). Scaling of SARS-CoV-2 RNA in Settled Solids from Multiple Wastewater Treatment Plants to Compare Incidence Rates of Laboratory-Confirmed COVID-19 in Their Sewersheds. Environmental Science & Technology Letters, 8 (5), 398-404. DOI: 10.1021/acs.estlett.1c00184

Rockey, N. C., Henderson, J. B., Chin, K., Raskin, L., & Wigginton, K. R. (2021). Predictive Modeling of Virus Inactivation by UV.  Environmental Science & Technology55 (5), 3322–3332. DOI: 10.1021/acs.est.0c07814

Crossette, E., Gumm, J., Langenfeld, K., Raskin, L., Duhaime, M., & Wigginton, K. (2021). Metagenomic quantification of genes with internal standards. MBio12 (1), e03173-20. DOI: 10.1128/mBio.03173-20

Wigginton, K. R., Arts, P. J., Clack, H. L., Fitzsimmons, W. J., Gamba, M., Harrison, K. R., LeBar, W., Lauring, A. S., Li, L., Roberts, W. W., Rockey, N. C., Torreblanca, J., Young, C., Anderegg, L. G., Cohn, A. M., Doyle, J. M., Meisenhelder, C. M., Raskin, L., Love, N. G., & Kaye, K. S. (2020). Validation of N95 Filtering Facepiece Respirator Decontamination Methods Available at a Large University Hospital. Open Forum Infectious Diseases8 (2), ofaa610. DOI: 10.1093/ofid/ofaa610

Rockey, N. C., Shen, Y., Haig, S., Wax, M., Yonts, J., Wigginton, K. R., Raskin, L., & Olson, T. M. (2021). Impact of service line replacement on lead, cadmium, and other drinking water quality parameters in Flint, Michigan.  Environ. Sci.: Water Res. Technol., 7, 797-808. DOI: 10.1039/D0EW00975J 

Schueler, J., Lansing, S., Crossette, E., Naas, K., Hurst, J., Raskin, L., Wigginton, K., Aga, D. S. (2021). Tetracycline, sulfadimethoxine, and antibiotic resistance gene dynamics during anaerobic digestion of dairy manure. J Environ Qual, 50 (3), 694-705. DOI: 10.1002/jeq2.20211

Langenfeld, K., Chin, K., Roy, A., Wigginton, K., Duhaime, M. B. (2021). Comparison of ultrafiltration and iron chloride flocculation in the preparation of aquatic viromes from contrasting sample types. PeerJ, 9, e11111. DOI: 10.7717/peerj.11111


Graham, K. E., Loeb, S. K., Wolfe, M. K., Catoe, D., Sinnott-Armstrong, N., Kim, S., Yamahara, K. M., Sassoubre, L. M., Mendoza Grijalva, L. M., Roldan-Hernandez, L., Langenfeld, K., Wigginton, K. R., & Boehm, A. B. (2021). SARS-CoV-2 RNA in Wastewater Settled Solids Is Associated with COVID-19 Cases in a Large Urban Sewershed. Environmental Science & Technology, 55 (1), 488–498. DOI: 10.1021/acs.est.0c06191

Rockey, N., Arts, P. J., Li, L., Harrison, K. R., Langenfeld, K., Fitzsimmons, W. J., Lauring, A. S., Love, N. G., Kaye, K. S., Raskin, L., Roberts, W. W., Hegarty, B., Wigginton, K. R. (2020). Humidity and Deposition Solution Play a Critical Role in Virus Inactivation by Heat Treatment of N95 Respirators. mSphere, 5 (5), e00588-20. DOI: 10.1128/mSphere.00588-20

Larson, D., Wigginton, K. (2020). Tracking COVID-19 with wastewater. Nature Biotechnology, 38, 1151–1153. DOI: 10.1038/s41587-020-0690-1

Bivins, A., North, D., Ahmad, A., Ahmed, W., Alm, E., Been, F., Bhattacharya, P., Bijlsma, L., Boehm, A., Brown, J., Buttiglieri, G., Calabro, V., Carducci, A., Castiglioni, S., Cetecioglu Gurol, Z., Chakraborty, S., Costa, F., Curcio, S., de los Reyes, F., Delgado Vela, J., Farkas, K., Fernandez-Casi, X., Gerba, C., Gerrity, D., Girones, R., Gonzalez, R., Haramoto, E., Harris, A., Holden, P., Islam, M. T., Jones, D., Kasprzyk-Hordern, B., Kitajima, M., Kotlarz, N., Kumar, M., Kuroda, K., La Rosa, G., Malpei, F., Mautus, M., McLellan, S., Medema, G., Meschke, J., Mueller, J., Newton, R., Nilsson, D., Noble, R., van Nuijs, A., Peccia, J., Perkins, T. A., Pickering, A., Rose, J., Sanchez, G., Smith, A., Stadler, L., Stauber, C., Thomas, K., van der Voorn, T., Wigginton, K., Zhu, K., Bibby, B. (2020). Wastewater-Based Epidemiology: Global Collaborative to Maximize Contributions in the Fight Against COVID-19. Environmental Science & Technology, 54 (13), 7754–7757. DOI: 10.1021/acs.est.0c02388 

Wigginton, K. R., Boehm, A. B. (2020). Environmental engineers and scientists have important roles to play in stemming outbreaks and pandemics caused by enveloped viruses. Environmental Science & Technology, 54 (7), 3736-3739. DOI: 10.1021/acs.est.0c01476

Rockey, N., Young, S., Kohn, T., Pecson, B. M., Wobus, C., Raskin, L., Wigginton, K. R. (2020). UV disinfection of human norovirus: evaluating infectivity using a genome-wide PCR-based approach. Environmental Science & Technology, 54 (5), 2851-2858. DOI: 10.1021/acs.est.9b05747

Goetsch, H. E., Love, N., Wigginton, K. R. (2020). Fate of Extracellular DNA in the Production of Fertilizers from Source-Separated Urine. Environmental Science & Technology, ASAP. DOI: 10.1021/acs.est.9b04263

Petrovich, M. L., Zilberman, A., Kaplan, A., Eliraz, G., Wang, Y., Langenfeld, K., Duhaime, M. B., Wigginton, K. R., Poretsky, R. S., Avisar, D., Wells, G. F. (2020). Microbial and Viral Communities and their Antibiotic Resistance Genes throughout a Hospital Wastewater Treatment System. Frontiers in microbiology, 11, 153. DOI: 10.3389/fmicb.2020.00153


Ye, Y., Zhao, L., Imperiale, M. J., & Wigginton, K. R. (2019). Integrated Cell Culture-Mass Spectrometry Method for Infectious Human Virus Monitoring. Environmental Science & Technology Letters, 6(7), 407-412. DOI: 10.1021/acs.estlett.9b00226

Hurst, J. J., Oliver, J. P., Schueler, J., Gooch, C., Lansing, S., Crossette, E., … & Sassoubre, L. M. (2019). Trends in antimicrobial resistance genes in manure blend pits and long-term storage across dairy farms with comparisons to antimicrobial usage and residual concentrations. Environmental science & technology, 53(5), 2405-2415. DOI: 10.1021/acs.est.8b05702

Xia, T., Kleinheksel, A., Lee, E., Qiao, Z., Wigginton, K., Clack, H. (2019). Inactivation of airborne viruses using a packed bed non-thermal plasma reactor. Journal of Physics D: Applied Physics. DOI: 10.1088/1361-6463/ab1466

Rockey, N., Bischel, H. N., Kohn, T., Pecson, B., & Wigginton, K. R. (2019). The utility of flow cytometry for potable reuse. Current Opinion in Biotechnology57, 42-49. DOI: 10.1016/j.copbio.2018.12.009


Qiao, Z., Ye, Y., Chang, P. H., Thirunarayanan, D., Wigginton, K. R. (2018). Nucleic acid photolysis by UV254 and the impact of virus encapsidation. Environmental Science & Technology, 52 (18), 10408-10415. DOI: 10.1021/acs.est.8b02308

Ye, Y., Chang, P. H., Hartert, J., Wigginton, K. R. (2018). Reactivity of Enveloped Virus Genome, Proteins, and Lipids with Free Chlorine and UV254. Environmental Science & Technology, 52 (14), 7698–7708. DOI: 10.1021/acs.est.8b00824

Nelson, K. L., Boehm, A. B., Davies-Colley, R. J., Dodd, M. C., Kohn, T., Linden, K. G., Liu, Y., Maraccini, P. A., McNeill, K., Mitch, W. A., Nguyen, T. H., Parker, K. M., Rodriguez, R. A., Sassoubre, L. M., Silverman, A. I., Wigginton, K. R., Zepp, R. G. (2018). Sunlight-mediated inactivation of health-relevant microorganisms in water: A review of mechanisms and modeling approaches. Environmental Sciences: Processes & Impacts, 20, 1089-1122. DOI: 10.1039/C8EM00047F 

Pruden, A., Alcalde, R. E., Alvarez, P. J. J., Ashbolt, N., Bischel, H., Capiro, N. L., Crossette, E., Frigon, D., Grimes, K., Haas, C. N., Ikuma, K., Kappell, A., LaPara, T., Kimbell, L., Li, M., Li, X., McNamara, P., Seo, Y., Sobsey, M. D., Sozzi, E., Navab-Daneshmand, T., Raskin, L., Riquelme, M. V., Vikesland, P., Wigginton, K. R., Zhou, Z. (2018). An Environmental Science and Engineering Framework for Combating Antimicrobial Resistance. Environmental Engineering Science, 35(10), 1005-1011. DOI: 10.1089/ees.2017.0520

Goetsch, H. E., Zhao, L., Gnegy, M., Imperiale, M. J., Love, N. G., Wigginton, K. R. (2018). The fate of urinary tract virus BK human polyomavirus in source-separated urine. Applied and Environmental Microbiology, 84 (7), e02374-17. DOI: 10.1128/AEM.02374-17


Mullen, R. A., Wigginton, K. R., Noe-Hays, A., Nace, K., Love, N. G., Bott, C. B., & Aga, D. S. (2017). Optimizing extraction and analysis of pharmaceuticals in human urine, struvite, food crops, soil, and lysimeter water by liquid chromatography-tandem mass spectrometry. Analytical Methods9 (41), 5952-5962. DOI: 10.1039/c7ay01801k

Vikesland, P. J., Pruden, A., Alvarez, P. J., Aga, D., Bürgmann, H., Li, X. D., … & Zhu, Y. G. (2017). Toward a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance. Environmental Science & Technology, 51 (22), 13061-13069. DOI: 10.1021/acs.est.7b03623

Cable, R. N., Beletsky, D., Beletsky, R., Wigginton, K., Locke, B. W., & Duhaime, M. B. (2017). Distribution and modeled transport of plastic pollution in the Great Lakes, the world’s largest freshwater resource. Frontiers in Environmental Science5, 45. DOI: 10.3389/fenvs.2017.00045

Chang, P. H., Juhrend, B., Olson, T. M., Marrs, C. F., & Wigginton, K. R. (2017). Degradation of extracellular antibiotic resistance genes with UV254 treatment. Environmental science & technology51 (11), 6185-6192. DOI: 10.1021/acs.est.7b01120

Bibby, K., Aquino de Carvalho, N., & Wigginton, K. (2017). Research needs for wastewater handling in virus outbreak response. Environmental Science & Technology, 51 (5), 2534-2535. DOI: 10.1021/acs.est.6b06492


Qiao, Z., & Wigginton, K. R. (2016). Direct and indirect photochemical reactions in viral RNA measured with RT-qPCR and mass spectrometry. Environmental Science & Technology50 (24), 13371-13379. DOI: 10.1021/acs.est.6b04281

Lahr, R. H., Goetsch, H. E., Haig, S. J., Noe-Hays, A., Love, N. G., Aga, D. S., Bott, C. B., Foxman, B., Jimenez, J., Luo, T., Nace, K., Ramadugu, K., & Wigginton, K. R. (2016). Urine bacterial community convergence through fertilizer production: Storage, pasteurization, and struvite precipitation. Environmental Science & Technology50(21), 11619-11626. DOI: 10.1021/acs.est.6b02094

Ye, Y., Ellenberg, R. M., Graham, K. E., & Wigginton, K. R. (2016). Survivability, partitioning, and recovery of enveloped viruses in untreated municipal wastewater. Environmental science & technology50 (10), 5077-5085. DOI: 10.1021/acs.est.6b00876


Wigginton, K. R., Ye, Y., & Ellenberg, R. M. (2015). Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle. Environmental Science: Water Research & Technology1 (6), 735-746. DOI: 10.1039/C5EW00125K.


Donham, J. E., Rosenfeldt, E. J., & Wigginton, K. R. (2014). Photometric hydroxyl radical scavenging analysis of standard natural organic matter isolates. Environmental Science: Processes & Impacts16(4), 764-769. DOI: 10.1039/C3EM00663H 


Sigstam, T., Gannon, G., Cascella, M., Pecson, B. M., Wigginton, K. R., & Kohn, T. (2013). Subtle differences in virus composition affect disinfection kinetics and mechanisms. Applied and environmental microbiology79 (11), 3455-3467. DOI: 10.1128/AEM.00663-13

Vikesland, P. J., Fiss, E. M., Wigginton, K. R., McNeill, K., & Arnold, W. A. (2013). Halogenation of bisphenol-A, triclosan, and phenols in chlorinated waters containing iodide. Environmental science & technology47(13), 6764-6772. DOI: 10.1021/es304927j


Wigginton, K. R., Pecson, B. M., Sigstam, T., Bosshard, F., & Kohn, T. (2012). Virus inactivation mechanisms: impact of disinfectants on virus function and structural integrity. Environmental science & technology46 (21), 12069-12078. DOI: 10.1021/es3029473

Wigginton, K. R., Menin, L., Sigstam, T., Gannon, G., Cascella, M., Hamidane, H. B., … & Kohn, T. (2012). UV Radiation Induces Genome‐Mediated, Site‐Specific Cleavage in Viral Proteins. ChemBioChem13 (6), 837-845. DOI: 10.1002/cbic.201100601

Wigginton, K. R., & Kohn, T. (2012). Virus disinfection mechanisms: the role of virus composition, structure, and function. Current opinion in virology2 (1), 84-89. DOI: 10.1016/j.coviro.2011.11.003


Mattle, M. J., Crouzy, B., Brennecke, M., Wigginton, K. R., Perona, P., & Kohn, T. (2011). Impact of virus aggregation on inactivation by peracetic acid and implications for other disinfectants. Environmental science & technology45 (18), 7710-7717. DOI: 10.1021/es201633s


Wigginton, K. R., Menin, L., Montoya, J. P., & Kohn, T. (2010). Oxidation of virus proteins during UV254 and singlet oxygen mediated inactivation. Environmental science & technology44 (14), 5437-5443. DOI: 10.1021/es100435a

Vikesland, P. J., & Wigginton, K. R. (2010). Nanomaterial enabled biosensors for pathogen monitoring-a review. Environmental science & technology44 (10), 3656-3669. DOI: 10.1021/es903704z

Wigginton, K. R., & Vikesland, P. J. (2010). Gold-coated polycarbonate membrane filter for pathogen concentration and SERS-based detection. Analyst135 (6), 1320-1326. DOI: 10.1039/B919270K 


Rule, K. L., & Vikesland, P. J. (2009). Surface-enhanced resonance Raman spectroscopy for the rapid detection of Cryptosporidium parvum and Giardia lamblia. Environmental science & technology43 (4), 1147-1152. DOI: 10.1021/es801531t


Fiss, E. M., Rule, K. L., & Vikesland, P. J. (2007). Formation of chloroform and other chlorinated byproducts by chlorination of triclosan-containing antibacterial products. Environmental science & technology41 (7), 2387-2394. DOI: 10.1021/es062227l


Rule, K. L., Ebbett, V. R., & Vikesland, P. J. (2005). Formation of chloroform and chlorinated organics by free-chlorine-mediated oxidation of triclosan. Environmental Science & Technology39 (9), 3176-3185. DOI: 10.1021/es048943+


Rule, K. L., Selvaraj, I. I., & Kirchmeier, R. L. (2001). Synthesis and characterization of per/polyfluorophenoxy derivatives of octachlorocyclotetraphosphazenes. Journal of fluorine chemistry112(2), 307-312. DOI: 10.1016/S0022-1139(01)00516-4