Wigginton Group Publications


Larson, D., Wigginton, K. (2020). Tracking COVID-19 with wastewater. Nature Biotechnology, 38, 1151–1153. DOI: 10.1038/s41587-020-0690-1

Bivins, A., North, D., Ahmad, A., Ahmed, W., Alm, E., Been, F., Bhattacharya, P., Bijlsma, L., Boehm, A., Brown, J., Buttiglieri, G., Calabro, V., Carducci, A., Castiglioni, S., Cetecioglu Gurol, Z., Chakraborty, S., Costa, F., Curcio, S., de los Reyes, F., Delgado Vela, J., Farkas, K., Fernandez-Casi, X., Gerba, C., Gerrity, D., Girones, R., Gonzalez, R., Haramoto, E., Harris, A., Holden, P., Islam, M. T., Jones, D., Kasprzyk-Hordern, B., Kitajima, M., Kotlarz, N., Kumar, M., Kuroda, K., La Rosa, G., Malpei, F., Mautus, M., McLellan, S., Medema, G., Meschke, J., Mueller, J., Newton, R., Nilsson, D., Noble, R., van Nuijs, A., Peccia, J., Perkins, T. A., Pickering, A., Rose, J., Sanchez, G., Smith, A., Stadler, L., Stauber, C., Thomas, K., van der Voorn, T., Wigginton, K., Zhu, K., Bibby, B. (2020). Wastewater-Based Epidemiology: Global Collaborative to Maximize Contributions in the Fight Against COVID-19. Environmental Science & Technology, 54 (13), 7754–7757. DOI: 10.1021/acs.est.0c02388 

Wigginton, K. R., Boehm, A. B. (2020). Environmental engineers and scientists have important roles to play in stemming outbreaks and pandemics caused by enveloped viruses. Environmental Science & Technology, 54 (7), 3736-3739. DOI: 10.1021/acs.est.0c01476

Rockey, N., Young, S., Kohn, T., Pecson, B. M., Wobus, C., Raskin, L., Wigginton, K. R. (2020). UV disinfection of human norovirus: evaluating infectivity using a genome-wide PCR-based approach. Environmental Science & Technology, 54 (5), 2851-2858. DOI: 10.1021/acs.est.9b05747

Goetsch, H. E., Love, N., Wigginton, K. R. (2020). Fate of Extracellular DNA in the Production of Fertilizers from Source-Separated Urine. Environmental Science & Technology, ASAP. DOI: 10.1021/acs.est.9b04263.

Petrovich, M. L., Zilberman, A., Kaplan, A., Eliraz, G., Wang, Y., Langenfeld, K., Duhaime, M. B., Wigginton, K. R., Poretsky, R. S., Avisar, D., Wells, G. F. (2020). Microbial and Viral Communities and their Antibiotic Resistance Genes throughout a Hospital Wastewater Treatment System. Frontiers in microbiology, 11, 153. DOI: 10.3389/fmicb.2020.00153


Ye, Y., Zhao, L., Imperiale, M. J., & Wigginton, K. R. (2019). Integrated Cell Culture-Mass Spectrometry Method for Infectious Human Virus Monitoring. Environmental Science & Technology Letters, 6(7), 407-412.DOI: 10.1021/acs.estlett.9b00226.

Hurst, J. J., Oliver, J. P., Schueler, J., Gooch, C., Lansing, S., Crossette, E., … & Sassoubre, L. M. (2019). Trends in antimicrobial resistance genes in manure blend pits and long-term storage across dairy farms with comparisons to antimicrobial usage and residual concentrations. Environmental science & technology, 53(5), 2405-2415. DOI: 10.1021/acs.est.8b05702.

Xia, T., Kleinheksel, A., Lee, E., Qiao, Z., Wigginton, K., Clack, H. (2019). Inactivation of airborne viruses using a packed bed non-thermal plasma reactor. Journal of Physics D: Applied Physics. DOI: 10.1088/1361-6463/ab1466.

Rockey, N., Bischel, H. N., Kohn, T., Pecson, B., & Wigginton, K. R. (2019). The utility of flow cytometry for potable reuse. Current Opinion in Biotechnology57, 42-49. DOI: 10.1016/j.copbio.2018.12.009.


Z. Qiao, Y. Ye, P. H. Chang, D. Thirunarayanan, K. R. Wigginton. (2018) “Nucleic acid photolysis by UV254 and the impact of virus encapsidation.” Environmental Science & Technology. DOI: 10.1021/acs.est.8b02308.

Y. Ye, P. H. Chang, J. Hartert, K. R. Wigginton. (2018) “Reactivity of Enveloped Virus Genome, Proteins, and Lipids with Free Chlorine and UV254.” Environmental Science & Technology, Vol 52 (14), pp 7698–7708.

K. L. Nelson, A. B. Boehm, R. J. Davies-Colley, M. C. Dodd, T. Kohn, K. G. Linden, Y. Liu, P. A. Maraccini, K. McNeill, W. A. Mitch, T. H. Nguyen, K. M. Parker, R. A. Rodriguez, L. M. Sassoubre, A. I. Silverman, K. R. Wigginton, R. G. Zepp. (2018) “Sunlight-mediated inactivation of health-relevant microorganisms in water: A review of mechanisms and modeling approaches.” Environmental Sciences: Processes & Impacts.

A. Pruden, R. E. Alcalde, P. JJ Alvarez, N. Ashbolt, H. Bischel, N. L. Capiro, E. Crossette, D. Frigon, K. Grimes, C. N. Haas, K. Ikuma, A. Kappell, T. LaPara, L. Kimbell, M. Li, X. Li, P. McNamara, Y. Seo, M. D. Sobsey, E. Sozzi, T. Navab-Daneshmand, L. Raskin, M. V. Riquelme, P. Vikesland, K. R. Wigginton, Z. Zhou. (2018) “An Environmental Science and Engineering Framework for Combating Antimicrobial Resistance.” Environmental Engineering Science. DOI: 10.1089/ees.2017.0520

H. E. Goetsch, L. Zhao, M. Gnegy, M. J. Imperiale, N. G. Love, K. R. Wigginton. (2018) “The fate of urinary tract virus BK human polyomavirus in source-separated urine.” Applied and Environmental Microbiology. DOI: 10.1128/AEM.02374-17.


R. A. Mullen, K. R. Wigginton, A. Noe-Hays, K. Nace, N. G. Love, C. B. Bottd, and D. S. Aga. (2017) “Optimizing extraction and analysis of pharmaceuticals in human urine, struvite, food crops, soil, and lysimeter water by liquid chromatography-tandem mass spectrometry.” Analytical Methods. DOI: 10.1039/c7ay01801k.

P. J. Vikesland, A. Pruden, P. J. J. Alvarez, D. S. Aga, H. Buergmann, X. Li, C. M. Manaia, I. M. Nambi, K. R. Wigginton, T. Zhang, and Y. Zhu. (2017) “Towards a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance.” Environmental Science & Technology. DOI: 10.1021/acs.est.7b03623.

R. N. Cable, D. Beletsky, R. Beletsky, K. Wigginton, B. W. Locke, and M. B. Duhaime. (2017) “Distribution and modeled transport of plastic pollution in the Great Lakes, the world’s largest freshwater resource.” Frontiers in Environmental Science, Vol 5, pp. 45. DOI: 10.3389/fenvs.2017.00045.

P. H. Chang, B. Juhrend, T. M. Olson, C. F. Marrs, and K. R. Wigginton. (2017) “Degradation of extracellular antibiotic resistance genes with UV254 treatment.” Environmental Science & Technology, Vol. 51 (11), pp. 6185-6192. DOI: 10.1021/acs.est.7b01120.

K. Bibby, N. A. Carvalho, and K. Wigginton. (2017) “Research Needs for Wastewater Handling in Virus Outbreak Response.” Environmental Science & Technology, Vol. 51, pp. 2534–2535. DOI: 10.1021/acs.est.6b06492.


Z. Qiao, and K. R. Wigginton. (2016) “Direct and indirect photochemical reactions in viral RNA measured with RT-qPCR and mass spectrometry.” Environmental Science & Technology, Vol. 50, pp. 13371-13379. DOI: 10.1021/acs.est.6b04281.

R. H. Lahr, H. E. Goetsch, S. J. Haig, A. Noe-Hays, N. G. Love, D. S. Aga∥, C. B. Bott, B. Foxman, J. Jimenez, T. Luo, K. Nace, K. Ramadugu, and K. R. Wigginton. (2016) “Urine bacterial community convergence through fertilizer production: Storage, pasteurization, and struvite precipitation.” Environmental Science & Technology, Vol. 50, pp. 11619-11626. DOI: 10.1021/acs.est.6b02094.

Y. Ye, R. M. Ellenberg, K. E. Graham, and K. R. Wigginton. (2016) “Survivability, partitioning, and recovery of enveloped viruses in untreated municipal wastewater.” Environmental Science & Technology, Vol. 50, pp. 5077-5085. DOI: 10.1021/acs.est.6b00876.


K. R. Wigginton, Y. Ye and R. M. Ellenberg. (2015) “Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle.” Environmental Science: Water Research and Technology, Vol. 1, pp. 735-746. DOI: 10.1039/C5EW00125K.


J. E. Donham, E. J. Rosenfeldt and K. R. Wigginton. (2014) “Photometric hydroxyl radical scavenging analysis of standard natural organic matter isolates.” Environ. Sci.: Processes Impacts, Vol. 16, pp. 764-769.


Sigstam, T, Gannon, G., Cascella, M., Pecson, B., Wigginton, K., Kohn, T. (2013) “Subtle differences in virus composition affect disinfection kinetics and mechanisms.” Applied and Environmental Microbiology, Vol. 79, pp. 3455-3467.

Vikesland, P.V., Fiss, E.M., Wigginton, K.R., McNeill, K., Arnold, W.A. (2013) “Halogenation of Bisphenol-A, Triclosan, and Chlorophenols in Chlorinated Waters Containing Iodide.” Environmental Science & Technology, Vol. 47, pp. 6764-6772.


Wigginton, K.R., Pecson, B.M., Sigstam, T., Bosshard, F., Kohn, T. (2012) “Virus inactivation mechanisms: impact of disinfectants on virus function and structural integrity,” Environmental Science & Technology, Vol. 46, pp. 12069-12078.

Wigginton, K.R., Menin, L., Sigstam, T., Gannon, G., Cascella, M., Hamidane, H.B., Tsybin, Y.O., Waridel, P., Kohn, T. (2012) “UV radiation induces genome-mediated, site-specific cleavage in viral protein,” ChemBioChem, Vol. 13, pp. 837-845.

Wigginton, K.R., Kohn, T. “Virus disinfection mechanisms: the role of virus composition, structure, and function,” (2012) Current Opinion in Virology, Current Opinion in Virology, Vol. 2, pp. 84-89.


Mattle, M.J., Crouzy, B., Brennecke M., Wigginton, K.R., Perona, P., and Kohn, T. (2011). “Impact of virus aggregation on inactivation by peracetic acid and implications for other disinfectants.” Environmental Science and Technology, Vol. 45, pp. 7710-7717.


Wigginton, K.R., Menin, L., Montoya, J.P., Kohn, T. (2010) “Oxidation of virus proteins during UV254 and singlet oxygen mediated inactivation.” Environmental Science and Technology, Vol. 44, pp. 5437–5443.

Vikesland, P.J., Wigginton, K.R. (2010) “Nanomaterial enabled biosensors for pathogen monitoring – a review.” Environmental Science and Technology, Vol. 44, pp. 3656-3669.

Wigginton, K.R., Vikesland, P.J. (2010) “Gold-coated polycarbonate membrane filter for pathogen concentration and SERS-based detection.” The Analyst, Vol. 135, pp. 1320-1326.


Rule, K.L., Vikesland, P.J. (2009) “Surface-enhanced resonance Raman spectroscopy for the rapid detection of Cryptosporidium parvum and Giardia lamblia,” Environmental Science and Technology, Vol. 43, pp. 1147-1152.


Fiss, M.E., Rule, K.L., Vikesland, P.J. (2007) “Formation of chloroform and other chlorinated byproducts by chlorination of Triclosan-containing antibacterial products.” Environmental Science and Technology, Vol. 41, pp. 2387-2394.


Rule, K.L., Ebbett, V.R., Vikesland, P.J., (2005). “Formation of chloroform and chlorinated organics by free-chlorine mediated oxidation of Triclosan” Environmental Science and Technology, Vol. 39, pp. 3176-3185.


Rule, K.L., Selvaraj, I.I., Kirchmeier, R.L. (2001). “Synthesis and characterization of per/polyfluorophenoxy derivatives of octachlorocyclotetraphosphazenes.” Journal of Fluorine Chemistry, Vol. 112, pp. 307-312 Sp. Iss.